Actin Based Cell Motility

Actin is central to the function of the cell and plays many important roles. Structural biology has provided us with a wealth of actin and actin-related protein structures in recent years, and using these structures along with a wide array of computational techniques we are able to look at the dynamics and interactions of actin at the molecular level. Our current work includes many different projects looking at the interaction and regulation of actin and actin associated proteins. A few of these projects are summarized below.