Welcome to the research lab of David Sept in the Department of Biomedical Engineering at the University of Michigan in Ann Arbor, Michigan.
Our lab is interested in understanding the dynamics, function, and organization of the cytoskeleton, in particular the molecular details underlying cell motility, and the structure, dynamics, and interaction of microtubules. In order to determine how actin filaments, microtubules, and their associated proteins work within the cell, we feel it is important to first understand the interactions that occur at the molecular level. We also perform work in the area of drug/inhibitor design, nanoparticle pharmacokinetics, and ligand gating in potassium channels. What makes all this research possible is the combination of advances in the fields of computer science and structural biology/biochemistry. See the research page for more detailed information.
If you are looking for information and files relating to our multisite ion models, you can find those details here.