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Publications

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Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding

A. L. Solon, Z. Tan, K. L. Schutt, L. Jepsen, S. E. Haynes, A. I. Nesvizhskii, D. Sept, J. Stumpff, R. Ohi and M. A. Cianfrocco

Sci Adv 7 (47) eabj9812, 2021.

Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin

T. Hotta, S. E. Haynes, T. L. Blasius, M. Gebbie, E. L. Eberhardt, D. Sept, M. Cianfrocco, K. J. Verhey, A. I. Nesvizhskii and R. Ohi

Curr Biol 31 (4) 900-907 e6, 2021.

Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms

B. G. Budaitis, S. Jariwala, L. Rao, Y. Yue, D. Sept, K. J. Verhey and A. Gennerich

J Cell Biol 220 (4) 2021.

Effects of Nucleotide and End-Dependent Actin Conformations on Polymerization

L. Jepsen and D. Sept

Biophys J 119 (9) 1800-1810, 2020.

Entropic effects enable life at extreme temperatures

Y. H. Kim, G. Leriche, K. Diraviyam, T. Koyanagi, K. Gao, D. Onofrei, J. Patterson, A. Guha, N. Gianneschi, G. P. Holland, M. K. Gilson, M. Mayer, D. Sept and J. Yang

Sci Adv 5 (5) eaaw4783, 2019.

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

B. G. Budaitis, S. Jariwala, D. N. Reinemann, K. I. Schimert, G. Scarabelli, B. J. Grant, D. Sept, M. J. Lang and K. J. Verhey

Elife 8 2019.

The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth

S. Chaaban, S. Jariwala, C. T. Hsu, S. Redemann, J. M. Kollman, T. Muller-Reichert, D. Sept, K. H. Bui and G. J. Brouhard

Dev Cell 2018.

Frequency-Based Analysis of Gramicidin A Nanopores Enabling Detection of Small Molecules with Picomolar Sensitivity

Y. H. Kim, L. Hang, J. L. Cifelli, D. Sept, M. Mayer and J. Yang

Anal Chem 90 (3) 1635-1642, 2018.

Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division

C. Chen, R. Cummings, A. Mordovanakis, A. J. Hunt, M. Mayer, D. Sept and Y. M. Yamashita

Elife 7 2018.

An electric-eel-inspired soft power source from stacked hydrogels

T. B. H. Schroeder, A. Guha, A. Lamoureux, G. VanRenterghem, D. Sept, M. Shtein, J. Yang and M. Mayer

Nature 552 (7684) 214-+, 2017.

Real-time shape approximation and fingerprinting of single proteins using a nanopore

E. C. Yusko, B. R. Bruhn, O. M. Eggenberger, J. Houghtaling, R. C. Rollings, N. C. Walsh, S. Nandivada, M. Pindrus, A. R. Hall, D. Sept, J. Li, D. S. Kalonia and M. Mayer

Nat Nanotechnol 12 (4) 360-367, 2017.

14-3-3 Regulates Actin Filament Formation in the Deep-Branching Eukaryote Giardia lamblia

J. Krtkova, J. Xu, M. Lalle, M. Steele-Ogus, G. C. M. Alas, D. Sept and A. R. Paredez

mSphere 2 (5) 2017.

Hybrid Lipids Inspired by Extremophiles and Eukaryotes Afford Serum-Stable Membranes with Low Leakage

T. Koyanagi, K. J. Cao, G. Leriche, D. Onofrei, G. P. Holland, M. Mayer, D. Sept and J. Yang

Chemistry 23 (28) 6757-6762, 2017.

Mechanisms of kinetic stabilization by the drugs paclitaxel and vinblastine

B. T. Castle, S. McCubbin, L. S. Prahl, J. N. Bernens, D. Sept and D. J. Odde

Mol Biol Cell 28 (9) 1238-1257, 2017.

Two Deafness-Causing Actin Mutations (DFNA20/26) Have Allosteric Effects on the Actin Structure

L. Jepsen, K. A. Kruth, P. A. Rubenstein and D. Sept

Biophys J 111 (2) 323-32, 2016.

Effects of Lipid Tethering in Extremophile-Inspired Membranes on H+/OH- Flux at Room Temperature

T. B. H. Schroeder, G. Leriche, T. Koyanagi, M. A. Johnson, K. N. Haengel, O. M. Eggenberger, C. L. Wang, Y. H. Kim, K. Diraviyam, D. Sept, J. Yang and M. Mayer

Biophysical Journal 110 (11) 2430-2440, 2016.

Novel alpha-tubulin mutation disrupts neural development and tubulin proteostasis

M. G. Hanson, J. Aiken, D. V. Sietsema, D. Sept, E. A. Bates, L. Niswander and J. K. Moore

Developmental Biology 409 (2) 406-419, 2016.

Hydrogel-assisted functional reconstitution of human P-glycoprotein (ABCB1) in giant liposomes

K. S. Horger, H. Liu, D. K. Rao, S. Shukla, D. Sept, S. V. Ambudkar and M. Mayer

Biochim Biophys Acta 1848 (2) 643-53, 2015.

Modeling large-scale dynamic processes in the cell: polarization, waves, and division

D. Sept and A. E. Carlsson

Quarterly Reviews of Biophysics 47 (3) 221-248, 2014.

A method for multiprotein assembly in cells reveals independent action of kinesins in complex

S. R. Norris, V. Soppina, A. S. Dizaji, K. I. Schimert, D. Sept, D. W. Cai, S. Sivaramakrishnan and K. J. Verhey

Journal of Cell Biology 207 (3) 393-406, 2014.

Assessing the barriers to image-guided drug delivery

G. M. Lanza, C. Moonen, J. R. Baker, E. Chang, Z. Cheng, P. Grodzinski, K. Ferrara, K. Hynynen, G. Kelloff, Y. E. K. Lee, A. K. Patri, D. Sept, J. E. Schnitzer, B. J. Wood, M. Q. Zhang, G. Zheng and K. Farahani

Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology 6 (1) 1-14, 2014.

Capping protein regulators fine-tune actin assembly dynamics

M. Edwards, A. Zwolak, D. A. Schafer, D. Sept, R. Dominguez and J. A. Cooper

Nat Rev Mol Cell Biol 15 (10) 677-89, 2014.

Genome-wide Analysis Reveals Novel and Discrete Functions for Tubulin Carboxy-Terminal Tails

J. Aiken, D. Sept, M. Costanzo, C. Boone, J. A. Cooper and J. K. Moore

Current Biology 24 (12) 1295-1303, 2014.

The unusual dynamics of parasite actin result from isodesmic polymerization

K. M. Skillman, C. I. Ma, D. H. Fremont, K. Diraviyam, J. A. Cooper, D. Sept and L. D. Sibley

Nat Commun 4 2285, 2013.

Properties of Microtubules with Isotropic and Anisotropic Mechanics

H. Sim and D. Sept

Cellular and Molecular Bioengineering 6 (4) 361-368, 2013.

Multisite ion models that improve coordination and free energy calculations in molecular dynamics simulations

A. Saxena and D. Sept

J. Chem. Theor. Comp. 9 (8) 3538-42, 2013.

A model for the interfacial kinetics of phospholipase D activity on long-chain lipids

S. Majd, E. C. Yusko, J. Yang, D. Sept and M. Mayer

Biophys J 105 (1) 146-53, 2013.

Synthetic chondramide A analogues stabilize filamentous actin and block invasion by Toxoplasma gondii

C. I. Ma, K. Diraviyam, M. E. Maier, D. Sept and L. D. Sibley

J Nat Prod 76 (9) 1565-72, 2013.

Mechanical properties of doubly stabilized microtubule filaments

T. L. Hawkins, D. Sept, B. Mogessie, A. Straube and J. L. Ross

Biophys J 104 (7) 1517-28, 2013.

Carboxyl Group Footprinting Mass Spectrometry and Molecular Dynamics Identify Key Interactions in the HER2-HER3 Receptor Tyrosine Kinase Interface

T. S. Collier, K. Diraviyam, J. Monsey, W. Shen, D. Sept and R. Bose

J Biol Chem 288 (35) 25254-64, 2013.

Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicity

P. Prangkio, E. C. Yusko, D. Sept, J. Yang and M. Mayer

PLoS One 7 (10) e47261, 2012.

Microtubules: sizing up the GTP cap

G. Brouhard and D. Sept

Curr Biol 22 (18) R802-3, 2012.

Single-particle characterization of abeta oligomers in solution

E. C. Yusko, P. Prangkio, D. Sept, R. C. Rollings, J. Li and M. Mayer

ACS Nano 6 (7) 5909-19, 2012.

Mechanism for CARMIL Protein Inhibition of Heterodimeric Actin-capping Protein

T. Kim, G. E. Ravilious, D. Sept and J. A. Cooper

Journal of Biological Chemistry 287 (19) 15251-15262, 2012.

Perturbations in Microtubule Mechanics from Tubulin Preparation

T. L. Hawkins, M. Mirigian, J. Q. Li, M. S. Yasar, D. L. Sackett, D. Sept and J. L. Ross

Cellular and Molecular Bioengineering 5 (2) 227-238, 2012.

Synthesis of Chondramide A Analogues with Modified beta-Tyrosine and Their Biological Evaluation

A. Zhdanko, A. Schmauder, C. I. Ma, L. D. Sibley, D. Sept, F. Sasse and M. E. Maier

Chem. Eur. J. 17 (47) 13349-57, 2011.

The interaction of cofilin with the actin filament

D. Y. Wong and D. Sept

J Mol Biol 413 (1) 97-105, 2011.

Drug-like Leads for Steric Discrimination between Substrate and Inhibitors of Human Acetylcholinesterase

S. A. Wildman, X. Zheng, D. Sept, J. T. Auletta, T. L. Rosenberry and G. R. Marshall

Chem Biol Drug Design 78 (4) 495-504, 2011.

Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites

K. M. Skillman, K. Diraviyam, A. Khan, K. Tang, D. Sept and L. D. Sibley

PLoS Pathog 7 (10) e1002280, 2011.

Pharmacokinetic modeling of tumor bioluminescence implicates efflux, and not influx, as the bigger hurdle in cancer drug therapy

H. Sim, K. Bibee, S. Wickline and D. Sept

Cancer Research 71 (3) 686-92, 2011.

An actin cytoskeleton with evolutionarily conserved functions in the absence of canonical actin-binding proteins

A. R. Paredez, Z. J. Assaf, D. Sept, L. Timofejeva, S. C. Dawson, C. J. Wang and W. Z. Cande

Proc. Natl. Acad. Sci. 108 (15) 6151-6, 2011.

An Epilepsy/Dyskinesia-Associated Mutation Enhances BK Channel Activation by Potentiating Ca2+ Sensing

J. Yang, G. Krishnamoorthy, A. Saxena, G. Zhang, J. Shi, H. Yang, K. Delaloye, D. Sept and J. Cui

Neuron 66 (6) 871-883, 2010.

Microtubule elasticity: connecting all-atom simulations with continuum mechanics

D. Sept and F. C. MacKintosh

Phys Rev Lett 104 (1) 018101, 2010.

F-actin structure destabilization and DNase I binding loop: fluctuations mutational cross-linking and electron microscopy analysis of loop states and effects on F-actin

Z. A. Oztug Durer, K. Diraviyam, D. Sept, D. S. Kudryashov and E. Reisler

J Mol Biol 395 (3) 544-57, 2010.

Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin

C. Ma, J. Tran, F. Gu, R. Ochoa, C. Li, D. Sept, K. Werbovetz and N. Morrissette

Antimicrob Agents Chemother 54 (4) 1453-60, 2010.

Overlapping and distinct functions for cofilin, coronin, and Aip1 in actin dynamics in vivo

M. C. Lin, B. J. Galletta, D. Sept, and J. A. Cooper

J Cell Sci 123 (Pt 8) 1329-42, 2010.

The interaction of capping protein with the barbed end of the actin filament

T. Kim, J. A. Cooper, and D. Sept

J Mol Biol 404 (5) 794-802, 2010.

An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability

E. D. Goley, A. Rammohan, E. A. Znameroski, E. N. Firat-Karalar, D. Sept and M. D. Welch

Proc Natl Acad Sci U S A 2010.

The Kinetics of Cooperative Cofilin Binding Reveals Two States of the Cofilin-Actin Filament

E. M. De La Cruz and D. Sept

Biophysical Journal 98 (9) 1893-1901, 2010.

A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential

J. R. Silva, H. Pan, D. Wu, A. Nekouzadeh, K. F. Decker, J. Cui, N. A. Baker, D. Sept and Y. Rudy

Proc Natl Acad Sci U S A 106 (27) 11102-6, 2009.

The Basic Concepts of Molecular Modeling

A. Saxena, D. Wong, K. Diraviyam and D. Sept

Methods in Enzymology: Computer Methods, Part B 467 307-334, 2009.

Making drug design second nature

D. L. Sackett and D. Sept

Nature Chemistry 1 (8) 596-597, 2009.

Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration

J. K. Moore, D. Sept, and J. A. Cooper

Proc Natl Acad Sci U S A 106 (13) 5147-52, 2009.

A22 disrupts the bacterial actin cytoskeleton by directly binding and inducing a low-affinity state in MreB

G. J. Bean, S. T. Flickinger, W. M. Westler, M. E. McCully, D. Sept, D. B. Weibel, and K. J. Amann

Biochemistry 48 (22) 4852-7, 2009.

Molecular modeling of the cytoskeleton

X. Zheng and D. Sept

Methods Cell Biol 84 893-910, 2008.

Nanoparticle pharmacokinetic profiling in vivo using magnetic resonance imaging

A. M. Neubauer, H. Sim, P. M. Winter, S. D. Caruthers, T. A. Williams, J. D. Robertson, D. Sept, G. M. Lanza and S. A. Wickline

Magn Reson Med 60 (6) 1353-61, 2008.

Taxol allosterically alters the dynamics of the tubulin dimer and increases the flexibility of microtubules

A. Mitra and D. Sept

Biophys J 95 (7) 3252-8, 2008.

Mapping the cofilin binding site on yeast G-actin by chemical cross-linking

E. E. Grintsevich, S. A. Benchaar, D. Warshaviak, P. Boontheung, F. Halgand, J. P. Whitelegge, K. F. Faull, R. R. Loo, D. Sept, J. A. Loo and E. Reisler

J Mol Biol 377 (2) 395-409, 2008.

Effects of solution crowding on actin polymerization reveal the energetic basis for nucleotide-dependent filament stability

K. B. Frederick, D. Sept, and E. M. De La Cruz

J Mol Biol 378 (3) 540-50, 2008.

New insights into the mechanism and regulation of actin capping protein

J. A. Cooper and D. Sept

Int Rev Cell Mol Biol 267 183-206, 2008.

Mathematical modeling of cell migration

A. E. Carlsson and D. Sept

Methods Cell Biol 84 911-37, 2008.

Nucleotide effects on the structure and dynamics of actin

X. Zheng, K. Diraviyam and D. Sept

Biophys J 93 (4) 1277-83, 2007.

First-contact time to a patch in a multidimensional potential well

L. Yang, D. Sept and A. E. Carlsson

Phys Rev E Stat Nonlin Soft Matter Phys 76 (2 Pt 1) 021911, 2007.

Microtubule polymerization: one step at a time

D. Sept

Curr Biol 17 (17) R764-6, 2007.

Mutations in alpha-tubulin confer dinitroaniline resistance at a cost to microtubule function

C. Ma, C. Li, L. Ganesan, J. Oak, S. Tsai, D. Sept and N. S. Morrissette

Mol Biol Cell 18 (12) 4711-20, 2007.

Structure/function analysis of the interaction of phosphatidylinositol 4,5-bisphosphate with actin-capping protein: implications for how capping protein binds the actin filament

K. Kim, M. E. McCully, N. Bhattacharya, B. Butler, D. Sept, and J. A. Cooper

J Biol Chem 282 (8) 5871-9, 2007.

Energetics and dynamics of constrained actin filament bundling

L. Yang, D. Sept and A. E. Carlsson

Biophys J 90 (12) 4295-304, 2006.

Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii

N. Sahoo, W. Beatty, J. Heuser, D. Sept, and L. D. Sibley

Mol Biol Cell 17 (2) 895-906, 2006.

Binding and interaction of dinitroanilines with apicomplexan and kinetoplastid alpha-tubulin

A. Mitra and D. Sept

J Med Chem 49 (17) 5226-31, 2006.

Myo1c binds phosphoinositides through a putative pleckstrin homology domain

D. E. Hokanson, J. M. Laakso, T. Lin, D. Sept and E. M. Ostap

Mol Biol Cell 17 (11) 4856-65, 2006.

A genetic dissection of Aip1p’s interactions leads to a model for Aip1p-cofilin cooperative activities

M. G. Clark, J. Teply, B. K. Haarer, S. C. Viggiano, D. Sept and D. C. Amberg

Mol Biol Cell 17 (4) 1971-84, 2006.

Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end

N. Bhattacharya, S. Ghosh, D. Sept and J. A. Cooper

J Biol Chem 281 (41) 31021-30, 2006.

The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating

G. Krishnamoorthy, J. Shi, D. Sept and J. Cui

J Gen Physiol 126 (3) 227-41, 2005.

Localization of the antimitotic peptide and depsipeptide binding site on beta-tubulin

A. Mitra and D. Sept

Biochemistry 43 (44) 13955-62, 2004.

The physical basis of microtubule structure and stability

D. Sept, N. A. Baker and J. A. McCammon

Protein Sci 12 (10) 2257-61, 2003.

Thermodynamics and kinetics of actin filament nucleation

D. Sept and J. A. McCammon

Biophys J 81 (2) 667-74, 2001.

Electrostatics of nanosystems: application to microtubules and the ribosome

N. A. Baker, D. Sept, S. Joseph, M. J. Holst and J. A. McCammon

Proc Natl Acad Sci U S A 98 (18) 10037-41, 2001.

Kinetic mechanism of end-to-end annealing of actin filaments

E. Andrianantoandro, L. Blanchoin, D. Sept, J. A. McCammon and T. D. Pollard

J Mol Biol 312 (4) 721-30, 2001.

Commitment to folded and aggregated states occurs late in interleukin-1 beta folding

J. M. Finke, L. A. Gross, H. M. Ho, D. Sept, B. H. Zimm and P. A. Jennings

Biochemistry 39 (50) 15633-42, 2000.

Annealing accounts for the length of actin filaments formed by spontaneous polymerization

D. Sept, J. Xu, T. D. Pollard and J. A. McCammon

Biophys J 77 (6) 2911-9, 1999.

A chemical kinetics model for microtubule oscillations

D. Sept, H. J. Limbach, H. Bolterauer and J. A. Tuszynski

J Theor Biol 197 (1) 77-88, 1999.

Computer simulations of actin polymerization can explain the barbed-pointed end asymmetry

D. Sept, A. H. Elcock and J. A. McCammon

J Mol Biol 294 (5) 1181-9, 1999.

Model for spatial microtubule oscillations

D. Sept

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 60 (1) 838-41, 1999.

Selected physical issues in the structure and function of microtubules

J. A. Tuszynski, B. Trpisova, D. Sept and J. A. Brown

J Struct Biol 118 (2) 94-106, 1997.